Thermogenic ingredients for the development of weight management food products

Adipose tissue is a vital connective tissue for all mammals. Its main role is to store energy in the form of lipids while insulating the body. It also contains a variety of crucial cells that act on the body’s immune and structural functions. Obesity is a medical condition defined by an excess of body fat. This disease increases the chances of developing conditions such as cardiovascular diseases, type 2 diabetes, cancer or depression,  decreasing the individual’s quality of life. Obesity is one of the leading preventable causes of death worldwide, mainly promoted by the intake of high-energy foods and low energy expenditure.

Thermogenic molecules

Some specific ingredients might contribute for one’s weight management goals with no need for extra energy expenditure or change in sedentary lifestyle. Foods such as chilli peppers, white and black pepper, ginger and cinnamon have in their composition capsaicin-like molecules, respectively piperine, gingerol and cinnamaldehyde.

Researchers found that the consumption of these food products promote the release of sympathetic-nerve mediated norepinephrine, naturally activating the brown adipose tissue thermogenesis by up-regulating the action of the uncoupling protein 1 in the mitochondria (UCP1) (Saito et. al. 2015). The UCP1 dissipates energy by oxidizing fatty acids and glucose to heat. Other ingredients, such as green tea or wasabi, also contribute to the up regulation of this protein.

Thermogenic and anti-obesity effects of capsacin-like food molecules, mediated by the release of sympathetic-nerve norepinephrine. This mechanism triggers the brown adipose tissue thermogenesis by up-regulating the action of the uncoupling protein 1 (UCP1) in the mitochondria. in Saito et. al. 2015

The consumption of these foods and spices might not always be possible in the desired concentration by consumers with weight issues. To overcome this limitation, companies may explore the potential of a new generation of anti-obesity, naturally thermogenic food products. It has been shown that the oral ingestion of capsules with capsinoids, substances naturally present in chili peppers, increases the energy expenditure mediated by the thermogenesis located in the brown adipose tissue (Yoneshiro et. al. 2012). Edible plant and spice extracts, naturally clean-label, mostly calorie free and widely available, may thus be the shining stars of a new generation of functional products for weight management issues, proven to be their safety in the public food and health system.

  • Yoneshiro, T. et al. (2012) Non pungent capsaicin analogs (capsinoids) increase energy expenditure through the activation of brown adipose tissue in humans. Am. J.Clin.Nutr. 95, 845–850

Author: CFER News

CFER is the Centre for Food Education and Research, expert in the development of new food and drink products, optimization of recipes for food businesses and companies and also a strong innovation centre in technological foods and drinks.

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